Florence is a city in and the county seat of Lauderdale County, Alabama, United States, in the state's northwest corner.According to the 2010 census, the city's population was 39,319.Florence is the largest and principal city of the Florence-Muscle Shoals Metropolitan Statistical Area. Florence is considered northwestern Alabama's primary economic hub.Annual tourism events include the W. C. Handy Music Festival in the summer and the Renaissance Faire in the fall. Landmarks in Florence include the Rosenbaum House, the only Frank Lloyd Wright-designed home located in Alabama.The type of municipal government is mayor-council.